Absolutely no. At least 1000+. GPO controller is just files lying in blast ball. The whole process of the application executed on the client, and everything you need from the controller in the case of GPO is to be available. Grouping rules, etc. policy is your personal pain. Collect all one-or two - as you then something troublshooting or change you? Crush 100500+ for every sneeze, you can grow a huge garden, in which you then get lost. Here you just need common sense and analyze your specific situation and your approach as clear as possible the name of the policy, and grouping of theme settings. The approach in grouping rules, in fact, similar to the group of users of computers in AD - you should not use group and everywhere to give rights-are on the users-computers are stupid, but to make 2-3 groups and only on them to differentiate - too that still pleasure and effectiveness)))
PS don't touch the default policy.